The main aim of present study was the investigation of the analgesic and CNS depressant activities of rutin hydrate. Anxiety and depression are wide spread psychiatric disorders effecting around 5% of population. Furthermore, it is difficult to predict how the patient will respond to any given treatment. In the traditional system of medicine, many plants and formulations have been used to treat anxiety and depressant activity for thousands of years. The analgesic activity was performed by using certain pharmacological screening methods like tail immersion method and eddy’s hot plate method on wistar albino rats, taking 50 mg and 100 mg of rutin hydrate. Diclofenac sodium is taken as standard analgesic drug. The present study was also designed to evaluate the central nervous system depressant activity of rutin hydrate. CNS depressant activity was tested by placing the rats in actophotometer. Rutin hydrate (100 mg) showed significant (p<0.001) basal reaction time compared to rutin hydrate (50 mg) treated rats. Rutin hydrate 100 mg>Rutin hydrate 50 mg>Diclofenac Na>Control. 50 mg and 100 mg concentration of rutin hydrate produced high analgesic activity when compared with the standard drug diclofenac Na. The results inferred that reduced aversion fear elicits anti anxiety activity. Rutin hydrate (100 mg) showed significant (p<0.001) spontaneous locomotor activity when compared to rutin hydrate (50 mg) treated rats. Diazepam 5 mg>Rutin hydrate 100 mg>Rutin hydrate 50 mg > Control. It was concluded that rutin hydrate also shows significant activity when compared with standard depressant drug diazepam.
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